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Office areas were custom designed specifically for each department. Based on staff input, workstations for the apparel, footwear and accessories divisions were each modified to accommodate how employees work as both individuals and in teams. The double-height sports center provides a state-of-the-art gymnasium for athletes and employees to challenge their skills. The facility includes a basketball and volleyball court, fitness center, batting cage, showers and locker rooms. An employee retail store offers easy access to equipment and merchandise. These on-site amenities exemplify ASICS' investment in creating an active employee environment and supporting sports excellence.
Interiors feature polished concrete floors, plywood-ribbed hallways and bold-colored accent walls. Modern furnishings are sleek yet ergonomic. The design also includes ASICS branding graphics that express the athletic nature of the company.ÿþAcademic journal Neuropharmacology 2014 OECD Field of science Biological sciences Keywords {Mechanotransduction / ASICs / "Ion channels" / Mechanoreceptor / Nociceptor / Touch / "Potassium channels"} Abstract of research paper on Biological sciences, author of scientific article Damir Omerbaai, Laura-Nadine Schuhmacher, Yinth-Andrea Bernal Sierra, Ewan St.
It is striking how diverse the consequences of Asic gene deletion are on mechanosensory function with both gain and loss of function effects being observed depending on sensory neuron type. We conclude that other, as yet unknown, molecular partners of ASIC proteins may be decisive in determining their precise physiological role in mechanosensory neurons. This article is part of the Special Issue entitled Acid-Sensing Ion Channels in the Nervous System'.It is well established that some members of the Deg/ENaC super family of amiloride sensitive ion channels can participate directly in the transduction of mechanical stimuli by sensory neurons in invertebrates.
Subsequent to the discovery of the mec-4 gene in C. elegans, a number of groups identified related converse rose gold genes in mammals that are expressed in sensory neurons and were shown to be gated by low pH, the first of which was ASIC1a (Waldmann et al., 1997b). These proteins, now designated acid sensing ion channels (ASICs), are coded by four genes that with alternative splicing generate 6 isoforms, each with distinct biophysical properties (ASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3 and ASIC4). The ASICs form Na+-selective and amiloride-sensitive ion channels and thus were attractive candidates for the mechanosensitive currents in adult sensory neurons that were shown by some workers to be [img]http://www.impressdispatch.com/images/shoes/converse rose gold-513rcg.jpg[/img] Na+-selective (Hu and Lewin, 2006; Lechner et al., 2009). |
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